A coastal cityscape with a sunset, high-rise buildings, and a marina.

San Antonio Vacations from $961

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Your San Antonio Vacation

From its rich history to its cultural experiences and beyond, there's a whole lot to love about San Antonio. Discover the wonders of this exciting city with a San Antonio vacation package that's tailor-made for you. Metromall Panama is just one of the must-see attractions to add to your sightseeing agenda during a trip to San Antonio. A few clicks is all it takes to craft the ideal San Antonio vacation on Expedia.

The Latest San Antonio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A resort with multiple swimming pools, a beach, and palm trees.
    Dec 21 - Dec 26

    Surfside Beachfront Suites by Playa Caracol Resorts + Flight

    Punta Chame
    5 nights
    3.5 star property
    8.2/10 - Very good (54 reviews)
    "Very good! A bit dusty the furniture and bedding not like mention on listing. Beautiful apartment with walking distance to the beach"
    Reviewed November 5, 2026
    Roundtrip • Trinidad (POS) - Panama City (PTY)
    POS - PTY • Nonstop PTY - POS • Nonstop
    $1,310
    $961
    per traveler
    found 21 hours ago
    Surfside Beachfront Suites by Playa Caracol Resorts
  • A multi-story building with balconies, arched windows, and decorative railings.
    Dec 25 - Dec 31

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    6 nights
    4.0 star property
    9.2/10 - Wonderful (1,005 reviews)
    "Beautiful historic hotel with very clean rooms and great wifi. Mini fridge, safe, bathrobes. Free welcome drink. Perfect location!"
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    Save 100% on your flight
    $4,365
    $2,158
    per traveler
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
    Dec 25 - Dec 31

    Megapolis Hotel Panamá + Flight

    San Francisco
    6 nights
    4.5 star property
    8.6/10 - Excellent (1,842 reviews)
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    Save 100% on your flight
    $2,760
    $1,533
    per traveler
    found 1 day ago
    Megapolis Hotel Panamá
  • A pool area with lounge chairs, umbrellas, and a bridge over the water.
    Jan 7 - Jan 12

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen Airport
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,813 reviews)
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,481
    $1,042
    per traveler
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
    Dec 25 - Dec 31

    Hotel Riu Plaza Panama + Flight

    Bella Vista
    6 nights
    5.0 star property
    9.0/10 - Wonderful (6,180 reviews)
    "Todo excelente, lo unico que no me gustó fué que me cobraron por el estacionamiento"
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,928
    $1,409
    per traveler
    found 1 day ago
    Hotel Riu Plaza Panama

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
Learn more about San Antonio

Rufina Alfaro

While you're in Rufina Alfaro, take in top sights like Metromall Panama and jump on the metro at San Antonio Station to see more of the city.

José Domingo Espinar

When in José Domingo Espinar, you can plan a visit to Estadio Rommel Fernandez and Metromall Panama, some noteworthy sights in the nearby area.

Omar Torrijos

While you're in Omar Torrijos, take in top sights like Templo Bahá'í and jump on the metro at San Isidro Station to see more of the city.

Victoriano Lorenzo

When in Victoriano Lorenzo and the surrounding area, you'll want to check out sights like Panama Viejo or Estadio Rommel Fernandez and hop on the metro to see more the city at San Miguelito Station or Paraiso Station.

A cable-stayed bridge spanning a river, surrounded by lush greenery and hills.

Cerro Viento

Shopping and restaurants are notable features of Cerro Viento. You might consider a stop by Metromall Panama while you're exploring the neighborhood.

What to do near San Antonio

Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

$99
per adult
94% of travelers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
See all activities near San Antonio

San Antonio Hotel Deals

An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
San Antonio
9.2 out of 10, Wonderful, (1,002 reviews)
$101 nightly
The price is $111
Nov 20 - Nov 21
Total with taxes and fees
Courtyard by Marriott Panama Metromall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.